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2-NMC Crystals is a Cathinone research chemical with a CAS number of 8378231-23-02. The chemical formula for 2-NMC Crystals is C12H17NO and the IUPAC Name is N-Methyl-N-p-tolyl-isobutyramide. The molecular mass is 191.00.

Since 2-NMC Crystals is however listed as, a Cathinone which is close to the same as ephedrine, methcathinone, and other amphetamines. We can assume that 2-NMC Crystals will work closely as other cathinones, which is found to encourage dopamine release while inhibiting the re-uptake of norepinephrine, epinephrine, and serotonin in the brain as well as the central nervous system.

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Synthetic cathinones made their appearance in the "drogosphere" in the early 2000s and today constitute one of the most widely used families of narcotics in Europe and North America. Juggling with the legality of their chemical structures, chemists and Reserach Chemicals websites have flooded the market with these diverse and varied substances with as yet unknown risks. The 2013 UN Report on Narcotics [1] reports the explosion in the consumption of these synthetic drugs; in the USA, “bath salts” are the most widely used drugs among 15-24 year olds after cannabis.

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Cathinone, real name benzoylethenamine, is a monoamine alkaloid found in Catha edulis (aka Khat leaf), a plant that grows mainly in East Africa. Chemically, its molecular structure resembles that of ephedrine, cathine and amphetamines. The name "synthetic cathinones" includes all derivatives of phenylalkylamines, and are often called "BK-amphetamines" because of its beta-ketone fraction. Its many derivatives include butylone, methylone, ethylone, methedrone, MDPV, 3-MMC, 4-MEC as well as dozens of others, but the most popular of these is mephedrone (4-MMC).

In 1967, a series of N-pyrrolidino ketone compounds was patented. The main compound in this series is 1-(methyl)-2-(pyrrolidinyl)-pentanone, more popularly known as pyrovalerone. Its synonyms are Centroton, Thymergix, Valerophenone, O-2371, and of course PV.

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Pyrovalerone (and by extension its derivatives) is structurally related to cathinones, and can therefore be considered a substituted cathinone.

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There are two key characteristics of pyrovalerones that distinguish them from primary cathinone derivatives; 1) a tertiary amine (not a primary or secondary amine), which is embedded in a five-membered ring, a heterocyclic pyrrolidine ring (4 carbon and one nitrogen). And 2) a five carbon structure (providing a pentiophenone structure as opposed to a propiophenone).

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In 1969, the methylenedioxyphenyl analogue of pyrovalerone, well known today by its abbreviation MDPV, was patented by a pharmaceutical company Boehringer Ingelheim. MDPV was never commercialized and remained an obscure stimulant until recently, when it became a popular research chemical.

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In summary, PV, as well as many analogs of it, are known to be ligands for monoamine transporters, with a preference for NET (Noradrenaline transporter) and DAT (Dopamine transporter), and for most , negligible interaction with SERT (serotonin transporter) (except naphyrone). In general, compounds of this class can be presumed to be potent CNS and cardiovascular stimulants.

Mephedrone was first synthesized in 1929 by Saem de Burnaga Sanchez under the name “toluyl-alpha-monomethylaminoethyl ketone” whose work was published in the Bulletin de la Société Chimique de France. It was in 2003 that this substance was “revisited” by an “underground” chemist using the pseudonym “Kinetic” who published the first description of the effects of mephedrone on the Hive website. He will describe among other things "this incredible feeling of well-being that I could not find in any drug except my beloved ecstasy (MDMA)".

It is then in Israel that a new page in the history of synthetic cathinones will be written. Indeed, as of 2004, a derivative of cathinones is sold legally in the country under the name of hagigat . Declared illegal after two years, this derivative saw its molecular structure modified, then was again marketed by the Israeli company Neorganics under the name of Neodoves Pills. In July 2008, the Israeli government made all derivatives of cathinone illegal, but these stimulants were nevertheless to know their hours of glory, this time in Europe and the United States.

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Between 2007 and 2010, mephedrone was sold legally on RC websites, most often under the name "bath salts" or "fertilizer (plant food)  ", until it was banned in the United Kingdom. United, a country at the forefront of Designer Drugs and where mephedrone was allegedly implicated in the deaths of several teenagers. From there, dozens of other cathinone derivatives were synthesized and marketed, some more successfully than others like methylone, butylone and MDPV.

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Today, most health authorities in Western countries have opted for a prohibition system that no longer only concerns a particular substance, but all of its real and future substituents, even if it means upsetting the pharmaceutical industry, which sees he takes a dim view of this blacklisting of these molecules whose potential clinical interest is therefore difficult to exploit. Nevertheless, the prohibition is difficult to enforce because of the great diversity of these new drugs and the lack of reliable and rapid diagnostic tools to identify them and distinguish - according to the specific legislation of each country - those which are legal from those who are no longer.

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" I haven't ordered since the ban and the last cathi I liked was pentedrone, synthesized by a US lab, it had a strawberry smell in the background which I liked. I still liked pentylone as a functional stim for every day +! And the MDPV to complete a mission at all costs, to finally get out of a comatose state, it's also the MDPV that caused the most damage around me 3 years ago! Well... Just shouldn't count on it every day, a week's worth was already not bad, and 3 dashes a day was enough for me.

Desired and undesirable effects

Like phenethylamines, in the absence of substitution on the phenyl ring, cathinones behave as a central nervous system (CNS) stimulant, but still with lower potency than the corresponding analog phenethylamine. The lower potency is caused by the β-keto group, which creates a molecule less able to cross the blood-brain barrier.

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Taken together, the main effects of synthetic cathinones are increased energy, empathy, the desire to reach out to others and to communicate, a feeling of intellectual and physical power, as well as an increase in libido. Depending on the particular substance, the effects are more or less similar to those of cocaine, amphetamine or MDMA.

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With regard to adverse effects, users report cardiac, psychiatric and neurological symptoms.

" Since I can't find mephedrone anymore I challenged myself to taste all the cathinones in case I find similar effects. Here is a first summary of my research. Even if there are still some missing from my list, I find it interesting to share this with you. My mode of consumption is the IV. Each time I first did a test with less than 0.1 g then my shots were 0.2. I consumed at least 1g each time (except for flephedrone), up to 5g for 3mmc in one evening (often the whole night).

-BUPHEDRONE ( 1 -Phenyl-2-methylaminobutan-1-one), the last one I tested: slight rise during injection, insomnia, appetite suppressant, slight euphoria. Quiet descent.

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-BUTYLONE ( bk -MBDB): no rise, insomnia, slight euphoria, desire to consume again a little more pronounced.

- PENTEDRONE (α-methylamino- valerophenone ): big rise during the injection, the product burns the veins a little, sweat and sweaty hands, the heart races and we feel great excitement. Very stimulating product, which makes you nervous or even irritable. The descent is more difficult.

- FLEPHEDRONE ( 4 FMC): no effects felt.

-Methylone ( 3,4 -methylenedioxy-N-methylcathinone): flash on injection. desire to express themselves, feeling of euphoria, manageable descent.

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-3mmc ( 3 methylmethcathinone): flash during injection. Empathogen and entactogen. Want to eat again very present, strong craving. Sexual arousal. Difficult descent (a priori it is specific to the injection).

-4MEC (4 methylethcathinone ): more intense flash during injection. Same effects as the 3mmc but softer. I would say that the 4mec makes a little more speed than the 3mmc. The descent is also difficult.

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Result of the races I retain a top 3 in these tests: The 3 mmc, the 4 mec and the methylone. A point common to all these cathinones: the acceleration of heartbeats and the appetite suppressant action.